TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

Ken J. Ishii (), Tatsukata Kawagoe, Shohei Koyama, Kosuke Matsui, Himanshu Kumar, Taro Kawai, Satoshi Uematsu, Osamu Takeuchi, Fumihiko Takeshita, Cevayir Coban and Shizuo Akira ()
Additional contact information
Ken J. Ishii: Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST),
Tatsukata Kawagoe: Laboratory of Host Defense, WPI Immunology Frontier Research Center,
Shohei Koyama: Laboratory of Host Defense, WPI Immunology Frontier Research Center,
Kosuke Matsui: Department of Host Defense,
Himanshu Kumar: Laboratory of Host Defense, WPI Immunology Frontier Research Center,
Taro Kawai: Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST),
Satoshi Uematsu: Laboratory of Host Defense, WPI Immunology Frontier Research Center,
Osamu Takeuchi: Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST),
Fumihiko Takeshita: Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan
Cevayir Coban: Laboratory of Host Defense, WPI Immunology Frontier Research Center,
Shizuo Akira: Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST),

Nature, 2008, vol. 451, issue 7179, 725-729

Abstract: DNA vaccines induce adaptive immune responses mainly via induction of type-I interferon. This paper shows that this occurs by a mechanism that is independent of the activation of nucleic acid binding Toll-like receptors. B and CD4+ T cell responses require activation of the TBK pathway in hematopoietic cells, whereas TBK1 in non-hematopoietic cells is critical for the activation of CD8+ T cells.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature06537 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:451:y:2008:i:7179:d:10.1038_nature06537

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06537

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().