The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

Nicole King (), M. Jody Westbrook, Susan L. Young, Alan Kuo, Monika Abedin, Jarrod Chapman, Stephen Fairclough, Uffe Hellsten, Yoh Isogai, Ivica Letunic, Michael Marr, David Pincus, Nicholas Putnam, Antonis Rokas, Kevin J. Wright, Richard Zuzow, William Dirks, Matthew Good, David Goodstein, Derek Lemons, Wanqing Li, Jessica B. Lyons, Andrea Morris, Scott Nichols, Daniel J. Richter, Asaf Salamov, Sequencing Jgi, Peer Bork, Wendell A. Lim, Gerard Manning, W. Todd Miller, William McGinnis, Harris Shapiro, Robert Tjian, Igor V. Grigoriev and Daniel Rokhsar ()
Additional contact information
Nicole King: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
M. Jody Westbrook: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Susan L. Young: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Alan Kuo: Walnut Creek, California 94598, USA
Monika Abedin: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Jarrod Chapman: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Stephen Fairclough: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Uffe Hellsten: Walnut Creek, California 94598, USA
Yoh Isogai: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Ivica Letunic: EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Michael Marr: Brandeis University, Waltham, Massachusetts 02454, USA
David Pincus: University of California, San Francisco, California 94158, USA
Nicholas Putnam: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Antonis Rokas: Vanderbilt University, Nashville, Tennessee 37235, USA
Kevin J. Wright: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Richard Zuzow: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
William Dirks: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Matthew Good: University of California, San Francisco, California 94158, USA
David Goodstein: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Derek Lemons: University of California, San Diego, La Jolla, California 92093, USA
Wanqing Li: Stony Brook University, Stony Brook, New York 11794, USA
Jessica B. Lyons: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Andrea Morris: University of Michigan, Ann Arbor, Michigan 48109, USA
Scott Nichols: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Daniel J. Richter: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Asaf Salamov: Walnut Creek, California 94598, USA
Sequencing Jgi: Walnut Creek, California 94598, USA
Peer Bork: EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Wendell A. Lim: University of California, San Francisco, California 94158, USA
Gerard Manning: Razavi Newman Bioinformatics Center, Salk Institute for Biological Studies, La Jolla, California 92037, USA
W. Todd Miller: Stony Brook University, Stony Brook, New York 11794, USA
William McGinnis: University of California, San Diego, La Jolla, California 92093, USA
Harris Shapiro: Walnut Creek, California 94598, USA
Robert Tjian: Department of Molecular and Cell Biology and the Center for Integrative Genomics,
Igor V. Grigoriev: Walnut Creek, California 94598, USA
Daniel Rokhsar: Department of Molecular and Cell Biology and the Center for Integrative Genomics,

Nature, 2008, vol. 451, issue 7180, 783-788

Abstract: Abstract Choanoflagellates are the closest known relatives of metazoans. To discover potential molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome of the unicellular choanoflagellate Monosiga brevicollis. The genome contains approximately 9,200 intron-rich genes, including a number that encode cell adhesion and signalling protein domains that are otherwise restricted to metazoans. Here we show that the physical linkages among protein domains often differ between M. brevicollis and metazoans, suggesting that abundant domain shuffling followed the separation of the choanoflagellate and metazoan lineages. The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans.

Date: 2008
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DOI: 10.1038/nature06617

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