A role for adult TLX-positive neural stem cells in learning and behaviour

Chun-Li Zhang, Yuhua Zou, Weimin He, Fred H. Gage () and Ronald M. Evans ()
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Chun-Li Zhang: Howard Hughes Medical Institute
Yuhua Zou: Gene Expression Laboratory
Weimin He: Gene Expression Laboratory
Fred H. Gage: Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Ronald M. Evans: Howard Hughes Medical Institute

Nature, 2008, vol. 451, issue 7181, 1004-1007

Abstract: Neural stem cells in learning The production of new neurons occurs in the adult brain, and appears to be influenced by external stimuli such as learning, exercise and stress. But it is not clear how the process is regulated or whether it is important for brain function. New work in knockout mice lacking the orphan nuclear receptor TLX, which is expressed in neural stem cells, suggests that adult neurogenesis plays a pivotal role in learning and memory. The mice had reduced stem-cell proliferation, and a marked decrease in spatial learning. But since other behaviours such as fear conditioning were unaffected, the new neurons appear to have a selective contribution to brain functions.

Date: 2008
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DOI: 10.1038/nature06562

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