HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

Zoltan Arany (), Shi-Yin Foo, Yanhong Ma, Jorge L. Ruas, Archana Bommi-Reddy, Geoffrey Girnun, Marcus Cooper, Dina Laznik, Jessica Chinsomboon, Shamina M. Rangwala, Kwan Hyuck Baek, Anthony Rosenzweig and Bruce M. Spiegelman ()
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Zoltan Arany: Harvard Medical School, Boston, Massachusetts 02115, USA
Shi-Yin Foo: Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA
Yanhong Ma: Harvard Medical School, Boston, Massachusetts 02115, USA
Jorge L. Ruas: Harvard Medical School, Boston, Massachusetts 02115, USA
Archana Bommi-Reddy: Harvard Medical School, Boston, Massachusetts 02115, USA
Geoffrey Girnun: Harvard Medical School, Boston, Massachusetts 02115, USA
Marcus Cooper: Harvard Medical School, Boston, Massachusetts 02115, USA
Dina Laznik: Harvard Medical School, Boston, Massachusetts 02115, USA
Jessica Chinsomboon: Harvard Medical School, Boston, Massachusetts 02115, USA
Shamina M. Rangwala: Novartis Institutes for Biomedical Research, Diabetes and Metabolism, Cambridge, Massachusetts 02139, USA
Kwan Hyuck Baek: Vascular Biology Program, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anthony Rosenzweig: Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Stem Cell Institute, Boston, Massachusetts 02215, USA
Bruce M. Spiegelman: Harvard Medical School, Boston, Massachusetts 02115, USA

Nature, 2008, vol. 451, issue 7181, 1008-1012

Abstract: Countering ischaemia The transcriptional regulator PGC-1α mediates many of the effects of exercise on skeletal muscle, including mitochondrial biogenesis and fibre-type switching. Now this protein has been found to activate a natural defence pathway that protects ischaemic tissues. PGC-1α is produced in response to hypoxia and nutrient deprivation, and it in turn induces VEGF to promote blood vessel formation. This pathway is separate from the hypoxia response pathway involving hypoxia inducible factor and may provide a novel therapeutic target for treating ischaemic diseases of the heart, brain and limbs.

Date: 2008
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DOI: 10.1038/nature06613

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