Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana Maria Cuervo and Daniel J. Klionsky ()
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Noboru Mizushima: Tokyo Medical and Dental University
Beth Levine: University of Texas Southwestern Medical Center
Ana Maria Cuervo: Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Daniel J. Klionsky: Cellular and Developmental Biology and Biological Chemistry, University of Michigan

Nature, 2008, vol. 451, issue 7182, 1069-1075

Abstract: Garbage in, all sorts out Until recently, autophagy, or cellular self-digestion, was thought of primarily as part of the cell's garbage disposal system. Now it is know to be involved in cellular protein and organelle degradation during development as well as during adaptations to changing environmental conditions. Many intriguing questions remain to be answered about this process. For example, how can this one pathway be involved in cytoprotection as well as cell death? What is the connection between autophagy and human disease or ageing? In a review, Mizushima et al. consider recent progress in the field.

Date: 2008
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DOI: 10.1038/nature06639

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