Cyclical DNA methylation of a transcriptionally active promoter

Raphaël Métivier (), Rozenn Gallais, Christophe Tiffoche, Christine Le Péron, Renata Z. Jurkowska, Richard P. Carmouche, David Ibberson, Peter Barath, Florence Demay, George Reid, Vladimir Benes, Albert Jeltsch, Frank Gannon and Gilles Salbert
Additional contact information
Raphaël Métivier: Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu
Rozenn Gallais: Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu
Christophe Tiffoche: Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu
Christine Le Péron: Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu
Renata Z. Jurkowska: Jacobs University Bremen, Campus Ring 1
Richard P. Carmouche: EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
David Ibberson: EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Peter Barath: Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu
Florence Demay: Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu
George Reid: EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Vladimir Benes: EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Albert Jeltsch: Jacobs University Bremen, Campus Ring 1
Frank Gannon: EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Gilles Salbert: Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu

Nature, 2008, vol. 452, issue 7183, 45-50

Abstract: Abstract Processes that regulate gene transcription are directly under the influence of the genome organization. The epigenome contains additional information that is not brought by DNA sequence, and generates spatial and functional constraints that complement genetic instructions. DNA methylation on CpGs constitutes an epigenetic mark generally correlated with transcriptionally silent condensed chromatin. Replication of methylation patterns by DNA methyltransferases maintains genome stability through cell division. Here we present evidence of an unanticipated dynamic role for DNA methylation in gene regulation in human cells. Periodic, strand-specific methylation/demethylation occurs during transcriptional cycling of the pS2/TFF1 gene promoter on activation by oestrogens. DNA methyltransferases exhibit dual actions during these cycles, being involved in CpG methylation and active demethylation of 5mCpGs through deamination. Inhibition of this process precludes demethylation of the pS2 gene promoter and its subsequent transcriptional activation. Cyclical changes in the methylation status of promoter CpGs may thus represent a critical event in transcriptional achievement.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature06544 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06544

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06544

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().