Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

Jyh-Rong Chao, Evan Parganas, Kelli Boyd, Cheol Yi Hong, Joseph T. Opferman and James N. Ihle ()
Additional contact information
Jyh-Rong Chao: Department of Biochemistry,
Evan Parganas: Department of Biochemistry,
Kelli Boyd: Animal Resources Center, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
Cheol Yi Hong: Department of Biochemistry,
Joseph T. Opferman: Department of Biochemistry,
James N. Ihle: Department of Biochemistry,

Nature, 2008, vol. 452, issue 7183, 98-102

Abstract: Insights into the function of Hax1 are provided by a study showing that Hax1 facilitates the processing of the mitochondrial protease HtrA2 by the mitochondrial rhomboid protease Parl. It is the protease activity of HtrA2 that is essential to suppress apoptosis in both lymphocytes and striatal neurons.

Date: 2008
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DOI: 10.1038/nature06604

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