Identification of a serotonin/glutamate receptor complex implicated in psychosis

Javier González-Maeso (), Rosalind L. Ang, Tony Yuen, Pokman Chan, Noelia V. Weisstaub, Juan F. López-Giménez, Mingming Zhou, Yuuya Okawa, Luis F. Callado, Graeme Milligan, Jay A. Gingrich, Marta Filizola, J. Javier Meana and Stuart C. Sealfon ()
Additional contact information
Javier González-Maeso: Department of Neurology,
Rosalind L. Ang: Department of Neurology,
Tony Yuen: Department of Neurology,
Pokman Chan: Department of Neurology,
Noelia V. Weisstaub: Department of Psychiatry,
Juan F. López-Giménez: Institute of Biomedical and Life Sciences, University of Glasgow
Mingming Zhou: Department of Psychiatry,
Yuuya Okawa: Department of Neurology,
Luis F. Callado: CIBER of Mental Health, and,
Graeme Milligan: Institute of Biomedical and Life Sciences, University of Glasgow
Jay A. Gingrich: Department of Psychiatry,
Marta Filizola: Department of Structural and Chemical Biology and,
J. Javier Meana: CIBER of Mental Health, and,
Stuart C. Sealfon: Department of Neurology,

Nature, 2008, vol. 452, issue 7183, 93-97

Abstract: Psychosis complex isolated New-generation antipsychotic drugs such as olanzapine and risperidone act by blocking neurotransmission by serotonin 2AR receptors; hallucinogens such as LSD also act via these receptors. And drugs that mimic the excitatory neurotransmitter glutamate at its mGluR2 receptor are also powerful antipsychotics. These and other lines of evidence suggest that the serotonin and glutamate neurotransmitter systems function abnormally in the brain in schizophrenia. This would seem to be confirmed with the surprising discovery of a functional complex containing the serotonin 2AR and mGluR2 receptors that is involved in the unique effects of chemical hallucinogens in cultured cells and mice. The balance of these two receptors is disrupted in the brains of schizophrenic subjects, further implicating this complex as a promising potential target for the treatment of psychosis.

Date: 2008
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature06612 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06612

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06612

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().