Multi-membrane hydrogels

Sébastien Ladet, Laurent David () and Alain Domard ()
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Sébastien Ladet: Université de Lyon, Université Lyon 1, UMR CNRS 5223, Ingénierie des Matériaux Polymères (IMP), Laboratoire des Matériaux Polymères et des Biomatériaux, 15 Boulevard A. Latarjet, Bâtiment ISTIL, F-69622 Villeurbanne Cedex, France
Laurent David: Université de Lyon, Université Lyon 1, UMR CNRS 5223, Ingénierie des Matériaux Polymères (IMP), Laboratoire des Matériaux Polymères et des Biomatériaux, 15 Boulevard A. Latarjet, Bâtiment ISTIL, F-69622 Villeurbanne Cedex, France
Alain Domard: Université de Lyon, Université Lyon 1, UMR CNRS 5223, Ingénierie des Matériaux Polymères (IMP), Laboratoire des Matériaux Polymères et des Biomatériaux, 15 Boulevard A. Latarjet, Bâtiment ISTIL, F-69622 Villeurbanne Cedex, France

Nature, 2008, vol. 452, issue 7183, 76-79

Abstract: A tissue of hydrogels Polysaccharide-based hydrogels show potential for drug delivery and tissue engineering applications, for instance as a matrix to boost natural tissue regeneration. Ladet et al. use a multi-step interrupted gelation process to generate complex hydrogels with multi-membrane 'onion-like' and tubular architectures. The new structures are made from chitosan or alginates, biocompatible natural polymers, and their novel layered structure creates vacant 'inter-membrane' spaces suitable for cell or drug introduction. The starting hydrogel can have any shape, and in principle any number of layers can be created. Initial experiments with chondrocyte cells cultured within a chitosan hydrogel suggest that the material has potential as a base for artificial tissues.

Date: 2008
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DOI: 10.1038/nature06619

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