Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

Kuan-Ming Chen, Elena Harjes, Phillip J. Gross, Amr Fahmy, Yongjian Lu, Keisuke Shindo, Reuben S. Harris () and Hiroshi Matsuo ()
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Kuan-Ming Chen: Molecular Biology and Biophysics
Elena Harjes: Molecular Biology and Biophysics
Phillip J. Gross: Molecular Biology and Biophysics
Amr Fahmy: Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Yongjian Lu: Molecular Biology and Biophysics
Keisuke Shindo: Molecular Biology and Biophysics
Reuben S. Harris: Molecular Biology and Biophysics
Hiroshi Matsuo: Molecular Biology and Biophysics

Nature, 2008, vol. 452, issue 7183, 116-119

Abstract: The cellular cytosine deaminase APOBEC3G inhibits replication of HIV lacking the viral protein Vif; here the NMR structure of a mutant form of the catalytic domain of APOBEC3G is reported, and a model for the APOBEC–DNA interaction is proposed.

Date: 2008
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DOI: 10.1038/nature06638

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