Transient cyclical methylation of promoter DNA

Sara Kangaspeska, Brenda Stride, Raphaël Métivier, Maria Polycarpou-Schwarz, David Ibberson, Richard Paul Carmouche, Vladimir Benes, Frank Gannon and George Reid ()
Additional contact information
Sara Kangaspeska: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Brenda Stride: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Raphaël Métivier: SPARTE, UMR CNRS, 6026, Université de Rennes I, Bâtiment 13, 35042 Cedex, Rennes, France
Maria Polycarpou-Schwarz: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
David Ibberson: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Richard Paul Carmouche: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Vladimir Benes: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
Frank Gannon: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
George Reid: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany

Nature, 2008, vol. 452, issue 7183, 112-115

Abstract: DNA changes tack Two papers in this issue report cycles of DNA methylation and demethylation of CpG dinucleotides at gene promoters. The findings contrast sharply with the prevailing view of DNA methylation as a stable epigenetic 'mark' capable of transmitting a specific pattern of gene expression through mitosis and into the daughter cells. Métivier et al. observed DNA methylation/demethylation cycles at the pS2 gene promoter during its activation by oestrogen, accompanied by cycling of DNA methyltransferases and other factors. And Kangaspeska et al. report cyclical DNA methylation at five active promoters including pS2 and the oestrogen receptor α.

Date: 2008
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DOI: 10.1038/nature06640

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