The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

Daniel A. Muruve, Virginie Pétrilli, Anne K. Zaiss, Lindsay R. White, Sharon A. Clark, P. Joel Ross, Robin J. Parks and Jurg Tschopp ()
Additional contact information
Daniel A. Muruve: Department of Medicine,
Virginie Pétrilli: University of Lausanne
Anne K. Zaiss: Biochemistry and Molecular Biology, University of Calgary, Alberta T2N 4N1, Canada
Lindsay R. White: Department of Medicine,
Sharon A. Clark: Department of Medicine,
P. Joel Ross: Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario K1Y 4E9, Canada
Robin J. Parks: Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario K1Y 4E9, Canada
Jurg Tschopp: University of Lausanne

Nature, 2008, vol. 452, issue 7183, 103-107

Abstract: Activation of inflammasomes leads to maturation of the pro-inflammatory cytokine IL-1β; this study adds DNA to the growing list of exogenous and endogenous inflammasome activators.

Date: 2008
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Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06664

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DOI: 10.1038/nature06664

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