A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing

Rouven Bingel-Erlenmeyer, Rebecca Kohler, Günter Kramer, Arzu Sandikci, Snježana Antolić, Timm Maier, Christiane Schaffitzel, Brigitte Wiedmann, Bernd Bukau and Nenad Ban ()
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Rouven Bingel-Erlenmeyer: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
Rebecca Kohler: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
Günter Kramer: Zentrum für Molekulare Biologie (ZMBH), Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Arzu Sandikci: Zentrum für Molekulare Biologie (ZMBH), Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Snježana Antolić: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
Timm Maier: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
Christiane Schaffitzel: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
Brigitte Wiedmann: Novartis Institutes for BioMedical Research, Inc., 500 Technology Square, Cambridge, Massachusetts, 02139, USA
Bernd Bukau: Zentrum für Molekulare Biologie (ZMBH), Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Nenad Ban: Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland

Nature, 2008, vol. 452, issue 7183, 108-111

Abstract: This study determines how peptide deformylase interacts with the ribosome and how protein synthesis is coupled to processing of newly made proteins.

Date: 2008
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DOI: 10.1038/nature06683

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