UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

You-Me Kim (), Melanie M. Brinkmann, Marie-Eve Paquet and Hidde L. Ploegh ()
Additional contact information
You-Me Kim: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Melanie M. Brinkmann: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Marie-Eve Paquet: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Hidde L. Ploegh: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA

Nature, 2008, vol. 452, issue 7184, 234-238

Abstract: The membrane protein UNC93B interacts with intracellular Toll-like receptors TLR7 and TLR9. This paper shows that UNC93B specifically controls TLR trafficking from the endoplasmic reticulum to the endolysosome but is not required for ligand recognition or signal initiation.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature06726 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:452:y:2008:i:7184:d:10.1038_nature06726

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06726

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().