Transcriptional repression mediated by repositioning of genes to the nuclear lamina

K. L. Reddy, J. M. Zullo, E. Bertolino and H. Singh ()
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K. L. Reddy: Howard Hughes Medical Institute,
J. M. Zullo: Howard Hughes Medical Institute,
E. Bertolino: The University of Chicago, GCIS W522, 929 East 57th Street, Chicago, Illinois 60637, USA
H. Singh: Howard Hughes Medical Institute,

Nature, 2008, vol. 452, issue 7184, 243-247

Abstract: Artificially tethering a chromosomal region to the inner nuclear membrane (INM) of mammalian cells results in repression of gene transcription in conjunction with accumulation of lamin and INM proteins, but not nuclear pore complexes, at the tethered region.

Date: 2008
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DOI: 10.1038/nature06727

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