SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis

Hye-Jung Han, Jose Russo, Yoshinori Kohwi () and Terumi Kohwi-Shigematsu ()
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Hye-Jung Han: Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Jose Russo: Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Yoshinori Kohwi: Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Terumi Kohwi-Shigematsu: Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA

Nature, 2008, vol. 452, issue 7184, 187-193

Abstract: Abstract Mechanisms underlying global changes in gene expression during tumour progression are poorly understood. SATB1 is a genome organizer that tethers multiple genomic loci and recruits chromatin-remodelling enzymes to regulate chromatin structure and gene expression. Here we show that SATB1 is expressed by aggressive breast cancer cells and its expression level has high prognostic significance (P 1,000 genes, reversing tumorigenesis by restoring breast-like acinar polarity and inhibiting tumour growth and metastasis in vivo. Conversely, ectopic SATB1 expression in non-aggressive (SKBR3) cells led to gene expression patterns consistent with aggressive-tumour phenotypes, acquiring metastatic activity in vivo. SATB1 delineates specific epigenetic modifications at target gene loci, directly upregulating metastasis-associated genes while downregulating tumour-suppressor genes. SATB1 reprogrammes chromatin organization and the transcription profiles of breast tumours to promote growth and metastasis; this is a new mechanism of tumour progression.

Date: 2008
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DOI: 10.1038/nature06781

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