Control of chromosome stability by the β-TrCP–REST–Mad2 axis

Daniele Guardavaccaro, David Frescas, N. Valerio Dorrello, Angelo Peschiaroli, Asha S. Multani, Timothy Cardozo, Anna Lasorella, Antonio Iavarone, Sandy Chang, Eva Hernando and Michele Pagano ()
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Daniele Guardavaccaro: and
David Frescas: and
N. Valerio Dorrello: and
Angelo Peschiaroli: and
Asha S. Multani: The MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Timothy Cardozo: NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, New York 10016, USA
Anna Lasorella: Institute for Cancer Genetics, Columbia University New York
Antonio Iavarone: Institute for Cancer Genetics, Columbia University New York
Sandy Chang: The MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Eva Hernando: and
Michele Pagano: and

Nature, 2008, vol. 452, issue 7185, 365-369

Abstract: The transcription factor REST has been implicated in tumourigenesis, and β-TrCP regulates REST degradation. REST, in turn, controls the chromosome stability by regulating the expression of spindle checkpoint protein Mad2, suggesting that this mechanism contributes to the roles of β-TrCP and REST in transformation.

Date: 2008
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DOI: 10.1038/nature06641

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