X-ray structure of a prokaryotic pentameric ligand-gated ion channel

Ricarda J. C. Hilf and Raimund Dutzler ()
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Ricarda J. C. Hilf: University of Zürich, Winterthurer Strasse 190, CH-8057 Zürich, Switzerland
Raimund Dutzler: University of Zürich, Winterthurer Strasse 190, CH-8057 Zürich, Switzerland

Nature, 2008, vol. 452, issue 7185, 375-379

Abstract: The X-ray structure of a prokaryotic pentameric ligand-gated ion channels (pLGIC) from the bacterium Erwinia chrysanthemi (ELIC) at 3.3 Å resolution is presented. This study reveals the first structure of a pLGIC at high resolution and provides an important model system for the investigation of the general mechanisms of ion permeation and gating within the family.

Date: 2008
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DOI: 10.1038/nature06717

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