SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

Thomas F. Westbrook, Guang Hu, Xiaolu L. Ang, Peter Mulligan, Natalya N. Pavlova, Anthony Liang, Yumei Leng, Rene Maehr, Yang Shi, J. Wade Harper () and Stephen J. Elledge ()
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Thomas F. Westbrook: Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics
Guang Hu: Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics
Xiaolu L. Ang: Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Peter Mulligan: Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Natalya N. Pavlova: Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics
Anthony Liang: Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics
Yumei Leng: Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics
Rene Maehr: Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Yang Shi: Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
J. Wade Harper: Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Stephen J. Elledge: Howard Hughes Medical Institute, Harvard Partners Center for Genetics and Genomics

Nature, 2008, vol. 452, issue 7185, 370-374

Abstract: The transcription factor REST plays important roles in opposing neuronal differentiation and in some human tumours. β-TrCP is identified as an important regulator of REST degradation.

Date: 2008
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DOI: 10.1038/nature06780

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