SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Eriko Michishita, Ronald A. McCord, Elisabeth Berber, Mitomu Kioi, Hesed Padilla-Nash, Mara Damian, Peggie Cheung, Rika Kusumoto, Tiara L. A. Kawahara, J. Carl Barrett, Howard Y. Chang, Vilhelm A. Bohr, Thomas Ried, Or Gozani and Katrin F. Chua ()
Additional contact information
Eriko Michishita: Gerontology and Metabolism, School of Medicine
Ronald A. McCord: Gerontology and Metabolism, School of Medicine
Elisabeth Berber: Gerontology and Metabolism, School of Medicine
Mitomu Kioi: School of Medicine
Hesed Padilla-Nash: Genetics Branch, and,
Mara Damian: Gerontology and Metabolism, School of Medicine
Peggie Cheung: and
Rika Kusumoto: Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
Tiara L. A. Kawahara: Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, California 94305, USA
J. Carl Barrett: Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, Maryland 20892, USA
Howard Y. Chang: Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, California 94305, USA
Vilhelm A. Bohr: Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
Thomas Ried: Genetics Branch, and,
Or Gozani: and
Katrin F. Chua: Gerontology and Metabolism, School of Medicine

Nature, 2008, vol. 452, issue 7186, 492-496

Abstract: The Sir2 family member SIRT6 is an NAD-dependent, histone H3 lysine 9 deacetylase enzyme that modulates telomeric chromatin and is required for stable association of WRN, the factor that is mutated in Werner Syndrome.

Date: 2008
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DOI: 10.1038/nature06736

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