Localization and functionality of microsporidian iron–sulphur cluster assembly proteins

Alina V. Goldberg, Sabine Molik, Anastasios D. Tsaousis, Karina Neumann, Grit Kuhnke, Frederic Delbac, Christian P. Vivares, Robert P. Hirt, Roland Lill () and T. Martin Embley ()
Additional contact information
Alina V. Goldberg: Institute for Cell and Molecular Biosciences, The Catherine Cookson Building, Newcastle University
Sabine Molik: Institut für Zytobiologie und Zytopathologie der Philipps Universität Marburg, Robert-Koch-Str. 6, 35033 Marburg, Germany
Anastasios D. Tsaousis: School of Biology, Devonshire Building, Newcastle University
Karina Neumann: Institut für Zytobiologie und Zytopathologie der Philipps Universität Marburg, Robert-Koch-Str. 6, 35033 Marburg, Germany
Grit Kuhnke: Institut für Zytobiologie und Zytopathologie der Philipps Universität Marburg, Robert-Koch-Str. 6, 35033 Marburg, Germany
Frederic Delbac: LBP, UMR CNRS 6023, Université Blaise Pascal, 24 Avenue des Landais, 63177 Aubiere Cedex, France
Christian P. Vivares: LBP, UMR CNRS 6023, Université Blaise Pascal, 24 Avenue des Landais, 63177 Aubiere Cedex, France
Robert P. Hirt: Institute for Cell and Molecular Biosciences, The Catherine Cookson Building, Newcastle University
Roland Lill: Institut für Zytobiologie und Zytopathologie der Philipps Universität Marburg, Robert-Koch-Str. 6, 35033 Marburg, Germany
T. Martin Embley: Institute for Cell and Molecular Biosciences, The Catherine Cookson Building, Newcastle University

Nature, 2008, vol. 452, issue 7187, 624-628

Abstract: What do mitosomes do? Microsporidia are highly specialized obligate intracellular parasites of other eukaryotes, including humans. They were long regarded as relics of an early stage of eukaryote evolution, before the acquisition of mitochondria. But recent research has complicated the picture, with the discovery that they contain a tiny mitochondrial remnant, called a mitosome. The function of the mitosome is a matter of debate, but microsporidian genomes are known to encode several components of the mitochondrial iron–sulphur-cluster machinery. Golberg et al. now describe the cloning, characterization and subcellular localization of several Fe–S-cluster components for two microsporidia. Although some components localize to the mitosome, others are cytosolic, raising questions about how their function is coordinated. The data support the suggestion that a key role of the mitosome is in the biosynthesis of cytosolic Fe–S proteins, including Nar1 and Rli1, that are vital for cell survival.

Date: 2008
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DOI: 10.1038/nature06606

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