Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

Frank Niessen, Florence Schaffner, Christian Furlan-Freguia, Rafal Pawlinski, Gourab Bhattacharjee, Jerold Chun, Claudia K. Derian, Patricia Andrade-Gordon, Hugh Rosen and Wolfram Ruf ()
Additional contact information
Frank Niessen: Departments of Immunology,
Florence Schaffner: Departments of Immunology,
Christian Furlan-Freguia: Departments of Immunology,
Rafal Pawlinski: Departments of Immunology,
Gourab Bhattacharjee: Departments of Immunology,
Jerold Chun: Molecular Biology, and,
Claudia K. Derian: Johnson & Johnson PRD, Spring House, Pennsylvania 19477, USA
Patricia Andrade-Gordon: Johnson & Johnson PRD, Spring House, Pennsylvania 19477, USA
Hugh Rosen: Departments of Immunology,
Wolfram Ruf: Departments of Immunology,

Nature, 2008, vol. 452, issue 7187, 654-658

Abstract: This paper examines the link between coagulation and systematic inflammation, and shows that coagulation proteases signal to dendritic cells by activating PAR1, resulting in activation of the shingolipid signalling component and dissemination of inflammation from the lymph nodes to the lungs.

Date: 2008
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DOI: 10.1038/nature06663

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