Tumour maintenance is mediated by eNOS

Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus and Christopher M. Counter ()
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Kian-Huat Lim: Duke University Medical Center, Durham, North Carolina 27710, USA
Brooke B. Ancrile: Duke University Medical Center, Durham, North Carolina 27710, USA
David F. Kashatus: Duke University Medical Center, Durham, North Carolina 27710, USA
Christopher M. Counter: Duke University Medical Center, Durham, North Carolina 27710, USA

Nature, 2008, vol. 452, issue 7187, 646-649

Abstract: Endothelial nitric oxide synthase (eNOS) is shown to have a role in cellular transformation and tumour maintenance downstream of Ras–AKT signalling. eNOS exerts its effect through nitrosylation and activation of endogenous wild-type Ras proteins.

Date: 2008
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DOI: 10.1038/nature06778

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