Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

Ilaria Malanchi, Hector Peinado, Deepika Kassen, Thomas Hussenet, Daniel Metzger, Pierre Chambon, Marcel Huber, Daniel Hohl, Amparo Cano, Walter Birchmeier and Joerg Huelsken ()
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Ilaria Malanchi: École Polytechnique Fédérale de Lausanne (EPFL)/ISREC (Swiss Institute for Experimental Cancer Research) and National Center of Competence in Research (NCCR) ‘Molecular Oncology’, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Hector Peinado: Instituto de Investigaciones Biomédicas ‘Alberto Sols’, CSIC-UAM, Arturo Duperier 4, 28029 Madrid, Spain
Deepika Kassen: École Polytechnique Fédérale de Lausanne (EPFL)/ISREC (Swiss Institute for Experimental Cancer Research) and National Center of Competence in Research (NCCR) ‘Molecular Oncology’, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Thomas Hussenet: École Polytechnique Fédérale de Lausanne (EPFL)/ISREC (Swiss Institute for Experimental Cancer Research) and National Center of Competence in Research (NCCR) ‘Molecular Oncology’, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Daniel Metzger: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), BP 10142, CU de Strasbourg, 67404 Illkirch, France
Pierre Chambon: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), BP 10142, CU de Strasbourg, 67404 Illkirch, France
Marcel Huber: Laboratory of Cutaneous Biology, Dermatology CHUV and FBM UNIL, Avenue de Beaumont 29, 1011 Lausanne, Switzerland
Daniel Hohl: Laboratory of Cutaneous Biology, Dermatology CHUV and FBM UNIL, Avenue de Beaumont 29, 1011 Lausanne, Switzerland
Amparo Cano: Instituto de Investigaciones Biomédicas ‘Alberto Sols’, CSIC-UAM, Arturo Duperier 4, 28029 Madrid, Spain
Walter Birchmeier: Max Delbrück Centrum, Robert-Roessle-Strasse 10, 13122 Berlin, Germany
Joerg Huelsken: École Polytechnique Fédérale de Lausanne (EPFL)/ISREC (Swiss Institute for Experimental Cancer Research) and National Center of Competence in Research (NCCR) ‘Molecular Oncology’, Chemin des Boveresses 155, 1066 Epalinges, Switzerland

Nature, 2008, vol. 452, issue 7187, 650-653

Abstract: Skin cancer target In a mouse model for skin cancer, β-catenin signalling is shown to be involved in the maintenance of a population of cancer stem cells. These cancer stem cells share properties with the normal stem cells found in the bulge of hair follicles and may therefore be derived from those cells. As β-catenin signalling is not required for normal skin homeostasis, it may be a suitable new target for skin cancer therapy.

Date: 2008
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DOI: 10.1038/nature06835

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