A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Thorgeir E. Thorgeirsson (), Frank Geller, Patrick Sulem, Thorunn Rafnar, Anna Wiste, Kristinn P. Magnusson, Andrei Manolescu, Gudmar Thorleifsson, Hreinn Stefansson, Andres Ingason, Simon N. Stacey, Jon T. Bergthorsson, Steinunn Thorlacius, Julius Gudmundsson, Thorlakur Jonsson, Margret Jakobsdottir, Jona Saemundsdottir, Olof Olafsdottir, Larus J. Gudmundsson, Gyda Bjornsdottir, Kristleifur Kristjansson, Halla Skuladottir, Helgi J. Isaksson, Tomas Gudbjartsson, Gregory T. Jones, Thomas Mueller, Anders Gottsäter, Andrea Flex, Katja K. H. Aben, Femmie de Vegt, Peter F. A. Mulders, Dolores Isla, Maria J. Vidal, Laura Asin, Berta Saez, Laura Murillo, Thorsteinn Blondal, Halldor Kolbeinsson, Jon G. Stefansson, Ingunn Hansdottir, Valgerdur Runarsdottir, Roberto Pola, Bengt Lindblad, Andre M. van Rij, Benjamin Dieplinger, Meinhard Haltmayer, Jose I. Mayordomo, Lambertus A. Kiemeney, Stefan E. Matthiasson, Hogni Oskarsson, Thorarinn Tyrfingsson, Daniel F. Gudbjartsson, Jeffrey R. Gulcher, Steinn Jonsson, Unnur Thorsteinsdottir, Augustine Kong and Kari Stefansson ()
Additional contact information
Thorgeir E. Thorgeirsson: deCODE Genetics
Frank Geller: deCODE Genetics
Patrick Sulem: deCODE Genetics
Thorunn Rafnar: deCODE Genetics
Anna Wiste: deCODE Genetics
Kristinn P. Magnusson: deCODE Genetics
Andrei Manolescu: deCODE Genetics
Gudmar Thorleifsson: deCODE Genetics
Hreinn Stefansson: deCODE Genetics
Andres Ingason: deCODE Genetics
Simon N. Stacey: deCODE Genetics
Jon T. Bergthorsson: deCODE Genetics
Steinunn Thorlacius: deCODE Genetics
Julius Gudmundsson: deCODE Genetics
Thorlakur Jonsson: deCODE Genetics
Margret Jakobsdottir: deCODE Genetics
Jona Saemundsdottir: deCODE Genetics
Olof Olafsdottir: deCODE Genetics
Larus J. Gudmundsson: deCODE Genetics
Gyda Bjornsdottir: deCODE Genetics
Kristleifur Kristjansson: deCODE Genetics
Halla Skuladottir: Department of Medical Oncology,
Helgi J. Isaksson: Department of Pathology,
Tomas Gudbjartsson: Department of Cardiothoracic Surgery,
Gregory T. Jones: Dunedin School of Medicine, University of Otago
Thomas Mueller: Konventhospital Barmherzige Brueder, 4020 Linz, Austria
Anders Gottsäter: Center for Vascular Diseases, University Hospital, MAS, 205 02 Malmö, Sweden
Andrea Flex: Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Universita Cattolica del Sacro Cuore School of Medicine
Katja K. H. Aben: Radboud University Nijmegen Medical Centre
Femmie de Vegt: Radboud University Nijmegen Medical Centre
Peter F. A. Mulders: Radboud University Nijmegen Medical Centre
Dolores Isla: University Hospital
Maria J. Vidal: University Hospital
Laura Asin: Nanotechnology Institute of Aragon
Berta Saez: Health Science Institute
Laura Murillo: Hospital Reina Sofia
Thorsteinn Blondal: Primary Health Care Centre, 101 Reykjavik, Iceland
Halldor Kolbeinsson: and
Jon G. Stefansson: and
Ingunn Hansdottir: Vogur SAA Addiction Treatment Center
Valgerdur Runarsdottir: Vogur SAA Addiction Treatment Center
Roberto Pola: Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Universita Cattolica del Sacro Cuore School of Medicine
Bengt Lindblad: Center for Vascular Diseases, University Hospital, MAS, 205 02 Malmö, Sweden
Andre M. van Rij: Dunedin School of Medicine, University of Otago
Benjamin Dieplinger: Konventhospital Barmherzige Brueder, 4020 Linz, Austria
Meinhard Haltmayer: Konventhospital Barmherzige Brueder, 4020 Linz, Austria
Jose I. Mayordomo: University Hospital
Lambertus A. Kiemeney: Radboud University Nijmegen Medical Centre
Stefan E. Matthiasson: School of Medicine, University of Iceland
Hogni Oskarsson: Therapeia
Thorarinn Tyrfingsson: Vogur SAA Addiction Treatment Center
Daniel F. Gudbjartsson: deCODE Genetics
Jeffrey R. Gulcher: deCODE Genetics
Steinn Jonsson: Landspitali University Hospital, 101 Reykjavik, Iceland
Unnur Thorsteinsdottir: deCODE Genetics
Augustine Kong: deCODE Genetics
Kari Stefansson: deCODE Genetics

Nature, 2008, vol. 452, issue 7187, 638-642

Abstract: Where there's smoke... With the advent of large genomic data sets, geneticists can examine at a new level the influence of genes on behaviour. Two groups have conducted genome-wide association studies involving lung cancer, and both find that sequences in the nicotinic acetylcholine receptor subunit gene cluster contribute susceptibility, although the groups took different paths to this result. Hung et al. suggest that this susceptibility is not related to smoking status or frequency, and show association with a specific amino acid change. Thorgeirsson et al. find that alleles present in a cluster of nicotinic acid receptor genes do not influence whether or not a person smokes, but do affect the number of cigarettes smoked per day, and are therefore also associated with risk of lung cancer and peripheral arterial disease. Either way, the possible potential of nicotinic acetylcholine receptors as drug targets is underlined.

Date: 2008
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DOI: 10.1038/nature06846

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