A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

Michael Groll, Barbara Schellenberg, André S. Bachmann (), Crystal R. Archer, Robert Huber, Tracy K. Powell, Steven Lindow, Markus Kaiser () and Robert Dudler ()
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Michael Groll: Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, Garching D-85747, Germany
Barbara Schellenberg: Zurich–Basel Plant Science Center, Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland
André S. Bachmann: Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA
Crystal R. Archer: Cancer Research Center of Hawaii, University of Hawaii at Manoa, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA
Robert Huber: Max-Planck-Institut für Biochemie
Tracy K. Powell: University of California, 111 Koshland Hall, Berkeley, California 94720-3102, USA
Steven Lindow: University of California, 111 Koshland Hall, Berkeley, California 94720-3102, USA
Markus Kaiser: Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, D-44227 Dortmund, Germany
Robert Dudler: Zurich–Basel Plant Science Center, Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland

Nature, 2008, vol. 452, issue 7188, 755-758

Abstract: Proteasome inhibitors Syringolin A, a virulence factor in Pseudomonas syringae pv. syringae, the cause of bacterial brown spot disease in beans, has been identified as an inhibitor of the eukaryotic proteasome, the cell's central protein degradation system. There is intense interest in proteasome inhibitors as possible drugs against cancer and other diseases. Syringolin A represents a new class of these agents, with considerable therapeutic potential.

Date: 2008
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DOI: 10.1038/nature06782

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