Chromatin dynamics during epigenetic reprogramming in the mouse germ line

Petra Hajkova, Katia Ancelin, Tanja Waldmann, Nicolas Lacoste, Ulrike C. Lange, Francesca Cesari, Caroline Lee, Genevieve Almouzni, Robert Schneider and M. Azim Surani ()
Additional contact information
Petra Hajkova: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Katia Ancelin: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Tanja Waldmann: Max-Planck-Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
Nicolas Lacoste: CNRS/Institute Curie, 26 rue d’Ulm, 75248 Paris cedex 05, France
Ulrike C. Lange: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Francesca Cesari: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Caroline Lee: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
Genevieve Almouzni: CNRS/Institute Curie, 26 rue d’Ulm, 75248 Paris cedex 05, France
Robert Schneider: Max-Planck-Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
M. Azim Surani: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK

Nature, 2008, vol. 452, issue 7189, 877-881

Abstract: Chromatin changes are examined in developing primordial germ cells during the time when the cells undergo a reprogramming step involving loss of DNA methylation and parental imprinting. Reprogramming is found to be linked to changes in histone modifications and to histone replacement through the action of histone chaperones. Histone replacement seems to occur subsequent to DNA demethylation.

Date: 2008
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DOI: 10.1038/nature06714

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