Integration of growth and specification in chick wing digit-patterning

Matthew Towers, Ruth Mahood, Yili Yin and Cheryll Tickle ()
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Matthew Towers: WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Ruth Mahood: WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Yili Yin: WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Cheryll Tickle: WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK

Nature, 2008, vol. 452, issue 7189, 882-886

Abstract: An additional function for Sonic hedgehog (Shh) in the limb bud is identified, namely the control of expression of cell cycle regulators, thereby controlling growth and specifying the size of the field in which the digit specification gradient operates. It is found that when Shh signalling was inhibited in chick limb buds, all the digit precursors formed anterior structures. In contrast, when cell proliferation was inhibited, all the anterior structures were lost and all the digit-precursors formed posterior structures.

Date: 2008
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DOI: 10.1038/nature06718

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