EconPapers    
Economics at your fingertips  
 

Integration of growth and specification in chick wing digit-patterning

Matthew Towers, Ruth Mahood, Yili Yin and Cheryll Tickle ()
Additional contact information
Matthew Towers: WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Ruth Mahood: WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Yili Yin: WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Cheryll Tickle: WTB/MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK

Nature, 2008, vol. 452, issue 7189, 882-886

Abstract: An additional function for Sonic hedgehog (Shh) in the limb bud is identified, namely the control of expression of cell cycle regulators, thereby controlling growth and specifying the size of the field in which the digit specification gradient operates. It is found that when Shh signalling was inhibited in chick limb buds, all the digit precursors formed anterior structures. In contrast, when cell proliferation was inhibited, all the anterior structures were lost and all the digit-precursors formed posterior structures.

Date: 2008
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature06718 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:452:y:2008:i:7189:d:10.1038_nature06718

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06718

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().

 
Page updated 2025-03-19
Handle: RePEc:nat:nature:v:452:y:2008:i:7189:d:10.1038_nature06718