NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

R. Grace Zhai (), Fan Zhang, P. Robin Hiesinger, Yu Cao, Claire M. Haueter and Hugo J. Bellen ()
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R. Grace Zhai: Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
Fan Zhang: Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
P. Robin Hiesinger: Howard Hughes Medical Institute, Baylor College of Medicine,
Yu Cao: Baylor College of Medicine
Claire M. Haueter: Howard Hughes Medical Institute, Baylor College of Medicine,
Hugo J. Bellen: Howard Hughes Medical Institute, Baylor College of Medicine,

Nature, 2008, vol. 452, issue 7189, 887-891

Abstract: Neuroprotection Abnormal protein aggregation is a feature of many neurodegenerative conditions. The NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase) is known to protect against induced neuro-degeneration in Drosophila. Now work in mice confirms an antidegenerative action for NMNAT and also a possible mechanism: it acts as a chaperone, helping other proteins to fold.

Date: 2008
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DOI: 10.1038/nature06721

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