A deadenylation negative feedback mechanism governs meiotic metaphase arrest

Eulàlia Belloc and Raúl Méndez ()
Additional contact information
Eulàlia Belloc: Centre for Genomic Regulation (CRG), Pompeu Fabra University (UPF), C/Dr Aiguader 88, 08003, Barcelona, Spain
Raúl Méndez: Centre for Genomic Regulation (CRG), Pompeu Fabra University (UPF), C/Dr Aiguader 88, 08003, Barcelona, Spain

Nature, 2008, vol. 452, issue 7190, 1017-1021

Abstract: A genome-wide screen for mRNAs that were polyadenylated at meiotic transitions noted that many contained an ARE, a deadenylation element, as well as a cytoplasmic polyadenylation element (CPE). One such mRNA encodes C3H-4, a protein that promotes shortening of polyA tails. The data suggest a model in which the early extension of polyadenylation through the CPE element leads to expression of C3H-4, which then acts in a negative feedback loop to deadenylate, and deactivate, those mRNAs that also contain an ARE, thereby allowing exit from metaphase.

Date: 2008
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature06809 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:452:y:2008:i:7190:d:10.1038_nature06809

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06809

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().