Crystal structure of the λ repressor and a model for pairwise cooperative operator binding

Steven Stayrook, Peera Jaru-Ampornpan, Jenny Ni, Ann Hochschild and Mitchell Lewis ()
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Steven Stayrook: University of Pennsylvania School of Medicine, 37th and Hamilton Walk, Philadelphia, Pennsylvania 19102-6059, USA
Peera Jaru-Ampornpan: University of Pennsylvania School of Medicine, 37th and Hamilton Walk, Philadelphia, Pennsylvania 19102-6059, USA
Jenny Ni: University of Pennsylvania School of Medicine, 37th and Hamilton Walk, Philadelphia, Pennsylvania 19102-6059, USA
Ann Hochschild: Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Mitchell Lewis: University of Pennsylvania School of Medicine, 37th and Hamilton Walk, Philadelphia, Pennsylvania 19102-6059, USA

Nature, 2008, vol. 452, issue 7190, 1022-1025

Abstract: A crystal structure of the intact, dimeric phage λ cI repressor bound to a DNA operator site reveals an unusual architecture allowing the repressor to adopt a conformation that facilitates cooperative binding to adjacent operator sites.

Date: 2008
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DOI: 10.1038/nature06831

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