Genetic variation in human NPY expression affects stress response and emotion

Zhifeng Zhou, Guanshan Zhu, Ahmad R. Hariri, Mary-Anne Enoch, David Scott, Rajita Sinha, Matti Virkkunen, Deborah C. Mash, Robert H. Lipsky, Xian-Zhang Hu, Colin A. Hodgkinson, Ke Xu, Beata Buzas, Qiaoping Yuan, Pei-Hong Shen, Robert E. Ferrell, Stephen B. Manuck, Sarah M. Brown, Richard L. Hauger, Christian S. Stohler, Jon-Kar Zubieta and David Goldman ()
Additional contact information
Zhifeng Zhou: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Guanshan Zhu: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Ahmad R. Hariri: Human Genetics, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Mary-Anne Enoch: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
David Scott: University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Rajita Sinha: Yale University School of Medicine, New Haven, Connecticut 06510, USA
Matti Virkkunen: University of Helsinki, 00014, Helsinki, Finland
Deborah C. Mash: University of Miami School of Medicine, Miami, Florida 33124, USA
Robert H. Lipsky: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Xian-Zhang Hu: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Colin A. Hodgkinson: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Ke Xu: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Beata Buzas: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Qiaoping Yuan: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Pei-Hong Shen: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Robert E. Ferrell: Human Genetics, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Stephen B. Manuck: Human Genetics, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Sarah M. Brown: Human Genetics, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Richard L. Hauger: San Diego VA Healthcare System and University of California, San Diego, California 92161, USA
Christian S. Stohler: School of Dentistry, University of Maryland, Baltimore, Maryland 21201, USA
Jon-Kar Zubieta: University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
David Goldman: Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA

Nature, 2008, vol. 452, issue 7190, 997-1001

Abstract: The Y factor An individual's ability to deal with stress and anxiety — risk factors for many diseases — varies widely across human populations and the factors contributing to emotional resilience are complex. A study led by researchers at the National Institute on Alcohol Abuse and Alcoholism now points to inherited variations in the expression of the natural anxiolytic peptide neuropeptide Y in the brain as a factor in determining why some people can withstand stress better than others.

Date: 2008
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DOI: 10.1038/nature06858

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