Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision

Ali D. Güler, Jennifer L. Ecker, Gurprit S. Lall, Shafiqul Haq, Cara M. Altimus, Hsi-Wen Liao, Alun R. Barnard, Hugh Cahill, Tudor C. Badea, Haiqing Zhao, Mark W. Hankins, David M. Berson, Robert J. Lucas (), King-Wai Yau and Samer Hattar ()
Additional contact information
Ali D. Güler: Johns Hopkins University, Baltimore, Maryland 21218, USA
Jennifer L. Ecker: Johns Hopkins University, Baltimore, Maryland 21218, USA
Gurprit S. Lall: Faculty of Life Sciences, University of Manchester
Shafiqul Haq: and
Cara M. Altimus: Johns Hopkins University, Baltimore, Maryland 21218, USA
Hsi-Wen Liao: and
Alun R. Barnard: Faculty of Life Sciences, University of Manchester
Hugh Cahill: and
Tudor C. Badea: Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Haiqing Zhao: Johns Hopkins University, Baltimore, Maryland 21218, USA
Mark W. Hankins: Visual Neuroscience, University of Oxford
David M. Berson: Brown University, Providence, Rhode Island 02912, USA
Robert J. Lucas: Faculty of Life Sciences, University of Manchester
King-Wai Yau: and
Samer Hattar: Johns Hopkins University, Baltimore, Maryland 21218, USA

Nature, 2008, vol. 453, issue 7191, 102-105

Abstract: Clock watching The mammalian retina has three types of light-sensing cells: rods, cones and melanopsin-containing cells. Rods and cones are involved in vision but have also been shown to contribute to light entrainment of the circadian clock. Now Güler et al. show that the non-image forming (circadian) role of rods and cones involves signalling via melanopsin-containing cells. This finding implies that people with troubled sleep or seasonal depression could benefit from light detection and melatonin suppression tests even if they are normally sighted.

Date: 2008
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DOI: 10.1038/nature06829

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