Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions

Stavroula Mili (), Konstadinos Moissoglu and Ian G. Macara ()
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Stavroula Mili: Center for Cell Signaling
Konstadinos Moissoglu: Cardiovascular Research Center, University of Virginia, HSC, Charlottesville, Virginia 22908-0577, USA
Ian G. Macara: Center for Cell Signaling

Nature, 2008, vol. 453, issue 7191, 115-119

Abstract: Polarized RNA RNA localization is important in many biological processes that involve the establishment or maintenance of polarity. Previously there has been no comprehensive identification of RNAs that localize during the polarization of mammalian cells, but that has now been achieved in a study of fibroblasts responding to migratory stimuli. A genome-wide screen identified more than 50 RNAs that localize to cell protrusions extending from mouse fibroblasts. The RNAs are anchored in granules concentrated at the 'plus' ends of microtubules, a novel RNA anchoring mechanism and an unanticipated function for microtubule plus ends. RNAs in these granules are associated with the tumour suppressor protein adenomatous polyposis coli (APC), a multi-function protein extensively studied as a component in the Wnt signalling pathway, also thought to be involved in cell migration, cell adhesion and mitosis. The cover image shows RNA granules (blue) at the tip of a cell protrusion, which has also been stained for actin filaments.

Date: 2008
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DOI: 10.1038/nature06888

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