Neutral metacommunity models predict fish diversity patterns in Mississippi–Missouri basin

Rachata Muneepeerakul (), Enrico Bertuzzo, Heather J. Lynch, William F. Fagan, Andrea Rinaldo and Ignacio Rodriguez-Iturbe ()
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Rachata Muneepeerakul: E-Quad, Princeton University, Princeton, New Jersey 08544, USA
Enrico Bertuzzo: E-Quad, Princeton University, Princeton, New Jersey 08544, USA
Heather J. Lynch: University of Maryland, College Park, Maryland 20742, USA
William F. Fagan: University of Maryland, College Park, Maryland 20742, USA
Andrea Rinaldo: Laboratory of Ecohydrology, Faculté ENAC, École Polytechnique Fédérale, CH-1015 Lausanne, Switzerland
Ignacio Rodriguez-Iturbe: E-Quad, Princeton University, Princeton, New Jersey 08544, USA

Nature, 2008, vol. 453, issue 7192, 220-222

Abstract: REST cure for stem cells The neuronal repressor protein known as REST or NRSF has a variety of effects — including both oncogenic and tumour suppressor activity — depending on cellular context. It is expressed at high levels in mouse embryonic stem cells but its function has not been understood. Now Singh et al. show that REST/NRSF is an element in the transcriptional network maintaining stem cell 'stemness'. It maintains self-renewal and pluripotency by blocking the expression of a microRNA that inhibits stem cell self-renewal and prompts them to differentiate into specific cell types.

Date: 2008
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DOI: 10.1038/nature06813

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