Imaging of Rab5 activity identifies essential regulators for phagosome maturation

Masahiro Kitano, Michio Nakaya, Takeshi Nakamura (), Shigekazu Nagata and Michiyuki Matsuda
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Masahiro Kitano: Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, and,
Michio Nakaya: Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Takeshi Nakamura: Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, and,
Shigekazu Nagata: Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Michiyuki Matsuda: Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, and,

Nature, 2008, vol. 453, issue 7192, 241-245

Abstract: Apoptotic cells are engulfed by phagocytes in a process that involves the GTPase Rab5. This paper shows that Rab5 promotes phagosome maturation, and Rab5 activation is induced by the guanine nucleotide exchange factor Gapex-5, which is recruited to phagosomes via microtubules.

Date: 2008
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DOI: 10.1038/nature06857

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