REST maintains self-renewal and pluripotency of embryonic stem cells

Sanjay K. Singh, Mohamedi N. Kagalwala, Jan Parker-Thornburg, Henry Adams and Sadhan Majumder ()
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Sanjay K. Singh: Department of Cancer Genetics,
Mohamedi N. Kagalwala: Department of Cancer Genetics,
Jan Parker-Thornburg: Department of Biochemistry and Molecular Biology,
Henry Adams: Department of Cancer Genetics,
Sadhan Majumder: Department of Cancer Genetics,

Nature, 2008, vol. 453, issue 7192, 223-227

Abstract: The neuronal repressor protein REST (also known as NRSF) maintains self renewal and pluripotency in embryonic stem cells through suppression of the miRNA-21, and is therefore a newly identified member of the transcriptional network maintaining stem cells in a pluripotent state. Knocking down its activity by using of siRNA or deletion of one allele caused loss of self renewal and led the cells to express differentiated markers.

Date: 2008
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DOI: 10.1038/nature06863

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