Chromatin decouples promoter threshold from dynamic range

Felix H. Lam, David J. Steger and Erin K. O’Shea ()
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Felix H. Lam: Howard Hughes Medical Institute, and Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 7 Divinity Avenue, Bauer 307, Cambridge, Massachusetts 02138, USA
David J. Steger: Howard Hughes Medical Institute, and Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 7 Divinity Avenue, Bauer 307, Cambridge, Massachusetts 02138, USA
Erin K. O’Shea: Howard Hughes Medical Institute, and Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 7 Divinity Avenue, Bauer 307, Cambridge, Massachusetts 02138, USA

Nature, 2008, vol. 453, issue 7192, 246-250

Abstract: By testing variants of the budding yeast phosphate response (PHO) genes, it is shown that the affinity of DNA binding sites that are accessible to a transcription factor determines the threshold for promoter activation, and that the binding sites within nucleosomal regions serve to influence the maximal expression of a gene once the nucleosomes are remodelled. Thus nucleosomes can decouple a promoter's threshold of activation from its dynamic range.

Date: 2008
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DOI: 10.1038/nature06867

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