TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Liang Zhou, Jared E. Lopes, Mark M. W. Chong, Ivaylo I. Ivanov, Roy Min, Gabriel D. Victora, Yuelei Shen, Jianguang Du, Yuri P. Rubtsov, Alexander Y. Rudensky, Steven F. Ziegler and Dan R. Littman ()
Additional contact information
Liang Zhou: The Kimmel Center for Biology and Medicine of the Skirball Institute, and,
Jared E. Lopes: Immunology Program Benaroya Research Institute Seattle
Mark M. W. Chong: The Kimmel Center for Biology and Medicine of the Skirball Institute, and,
Ivaylo I. Ivanov: The Kimmel Center for Biology and Medicine of the Skirball Institute, and,
Roy Min: The Kimmel Center for Biology and Medicine of the Skirball Institute, and,
Gabriel D. Victora: The Kimmel Center for Biology and Medicine of the Skirball Institute, and,
Yuelei Shen: The Kimmel Center for Biology and Medicine of the Skirball Institute, and,
Jianguang Du: Immunology Program Benaroya Research Institute Seattle
Yuri P. Rubtsov: Howard Hughes Medical Institute, University of Washington Seattle, Washington 98195, USA
Alexander Y. Rudensky: Howard Hughes Medical Institute, University of Washington Seattle, Washington 98195, USA
Steven F. Ziegler: Immunology Program Benaroya Research Institute Seattle
Dan R. Littman: The Kimmel Center for Biology and Medicine of the Skirball Institute, and,

Nature, 2008, vol. 453, issue 7192, 236-240

Abstract: The cytokine TFG-β contributes to the differentiation of both regulatory T cells and TH17 cells. This paper shows that in intestinal lamina propria cell lineage differentiation depends on the local TFG-β concentration.

Date: 2008
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DOI: 10.1038/nature06878

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