Human metabolic phenotype diversity and its association with diet and blood pressure

Elaine Holmes, Ruey Leng Loo, Jeremiah Stamler, Magda Bictash, Ivan K. S. Yap, Queenie Chan, Tim Ebbels, Maria De Iorio, Ian J. Brown, Kirill A. Veselkov, Martha L. Daviglus, Hugo Kesteloot, Hirotsugu Ueshima, Liancheng Zhao, Jeremy K. Nicholson () and Paul Elliott ()
Additional contact information
Elaine Holmes: Biomolecular Medicine, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus
Ruey Leng Loo: Biomolecular Medicine, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus
Jeremiah Stamler: Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Magda Bictash: Biomolecular Medicine, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus
Ivan K. S. Yap: Biomolecular Medicine, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus
Queenie Chan: Imperial College London, St Mary’s Campus
Tim Ebbels: Biomolecular Medicine, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus
Maria De Iorio: Imperial College London, St Mary’s Campus
Ian J. Brown: Imperial College London, St Mary’s Campus
Kirill A. Veselkov: Biomolecular Medicine, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus
Martha L. Daviglus: Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Hugo Kesteloot: Akademisch Ziekenhuis St Rafael, Leuven B-3000, Belgium
Hirotsugu Ueshima: Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan
Liancheng Zhao: Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences
Jeremy K. Nicholson: Biomolecular Medicine, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington Campus
Paul Elliott: Imperial College London, St Mary’s Campus

Nature, 2008, vol. 453, issue 7193, 396-400

Abstract: Metabolic profiling: Broad-brush epidemiology Metabolic profiling — the analysis of the relative levels of many different metabolites in blood or urine — can reveal a lot about how diet and lifestyle contribute to risks for certain diseases. Profiling of urine samples from more than 4,000 individuals taking part in the INTERMAP epidemiological study demonstrates significant differences in metabolism both from country to country and within populations. Metabolites discriminating across populations were linked to data on blood pressure, a major risk factor for coronary heart disease and stroke. Formate, alanine and hippurate excretion emerged as markers related to blood pressure. Overall the data show that lifestyle is a dominant feature in determining metabolism. This work lays the foundation for a 'metabolome-wide association' approach to molecular epidemiology.

Date: 2008
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DOI: 10.1038/nature06882

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