Nucleosome organization in the Drosophila genome

Travis N. Mavrich, Cizhong Jiang, Ilya P. Ioshikhes, Xiaoyong Li, Bryan J. Venters, Sara J. Zanton, Lynn P. Tomsho, Ji Qi, Robert L. Glaser, Stephan C. Schuster, David S. Gilmour, Istvan Albert and B. Franklin Pugh ()
Additional contact information
Travis N. Mavrich: Center for Gene Regulation, and,
Cizhong Jiang: Center for Gene Regulation, and,
Ilya P. Ioshikhes: Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
Xiaoyong Li: Berkeley Drosophila Transcription Network Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA
Bryan J. Venters: Center for Gene Regulation, and,
Sara J. Zanton: Center for Gene Regulation, and,
Lynn P. Tomsho: Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Ji Qi: Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Robert L. Glaser: Wadsworth Center, State University of New York, Albany, New York 12201-2002, USA
Stephan C. Schuster: Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
David S. Gilmour: Center for Gene Regulation, and,
Istvan Albert: Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
B. Franklin Pugh: Center for Gene Regulation, and,

Nature, 2008, vol. 453, issue 7193, 358-362

Abstract: Abstract Comparative genomics of nucleosome positions provides a powerful means for understanding how the organization of chromatin and the transcription machinery co-evolve. Here we produce a high-resolution reference map of H2A.Z and bulk nucleosome locations across the genome of the fly Drosophila melanogaster and compare it to that from the yeast Saccharomyces cerevisiae. Like Saccharomyces, Drosophila nucleosomes are organized around active transcription start sites in a canonical -1, nucleosome-free region, +1 arrangement. However, Drosophila does not incorporate H2A.Z into the -1 nucleosome and does not bury its transcriptional start site in the +1 nucleosome. At thousands of genes, RNA polymerase II engages the +1 nucleosome and pauses. How the transcription initiation machinery contends with the +1 nucleosome seems to be fundamentally different across major eukaryotic lines.

Date: 2008
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DOI: 10.1038/nature06929

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