Wound repair and regeneration

Geoffrey C. Gurtner, Sabine Werner, Yann Barrandon and Michael T. Longaker
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Geoffrey C. Gurtner: Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Sabine Werner: Institute of Cell Biology, Swiss Federal Institute of Technology (ETH), Schafmattstrasse 18, HPM D42
Yann Barrandon: Centre Hospitalier Universitaire Vaudois, Chirurgie Éxperimentale, Pavillon 4
Michael T. Longaker: Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine

Nature, 2008, vol. 453, issue 7193, 314-321

Abstract: Abstract The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.

Date: 2008
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DOI: 10.1038/nature07039

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