Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

Lei Yang, Mark H. Soonpaa, Eric D. Adler, Torsten K. Roepke, Steven J. Kattman, Marion Kennedy, Els Henckaerts, Kristina Bonham, Geoffrey W. Abbott, R. Michael Linden, Loren J. Field and Gordon M. Keller ()
Additional contact information
Lei Yang: The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
Mark H. Soonpaa: Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Indiana 46202, USA
Eric D. Adler: The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
Torsten K. Roepke: Weill Medical College of Cornell University, 520 East 70th Street, New York, New York 10021, USA
Steven J. Kattman: McEwen Centre for Regenerative Medicine, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Marion Kennedy: McEwen Centre for Regenerative Medicine, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada
Els Henckaerts: King’s College London
Kristina Bonham: VistaGen Therapeutics Inc., 384 Oyster Point Boulevard, Suite 8, San Francisco, California 94080, USA
Geoffrey W. Abbott: Weill Medical College of Cornell University, 520 East 70th Street, New York, New York 10021, USA
R. Michael Linden: The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
Loren J. Field: Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Indiana 46202, USA
Gordon M. Keller: The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA

Nature, 2008, vol. 453, issue 7194, 524-528

Abstract: Embryonic stem cells: Take heart from a growth factor cocktail A method for differentiation and isolation of one of the earliest human cardiac progenitors from human embryonic stem cells has been developed. By supplying a cocktail of growth factors at the appropriate stage of development, these cells can form cardiac, endothelial and vascular smooth muscle in vitro and, when transplanted, in vivo. When plated in culture, they can form populations of contracting cardiomyocytes. Transplantation of the cells into damaged mice hearts improved cardiac function. These cells will be useful for the study of cardiac development, and provide an enriched source of progenitors for engineering cardiovascular tissue in vitro and for transplantation to large animal models of heart disease.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature06894 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:453:y:2008:i:7194:d:10.1038_nature06894

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06894

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().