Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

Oliver H. Tam, Alexei A. Aravin, Paula Stein, Angelique Girard, Elizabeth P. Murchison, Sihem Cheloufi, Emily Hodges, Martin Anger, Ravi Sachidanandam, Richard M. Schultz and Gregory J. Hannon ()
Additional contact information
Oliver H. Tam: Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Alexei A. Aravin: Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Paula Stein: University of Pennsylvania, 433 South University Avenue, 205 Lynch Laboratories, Philadelphia, Pennsylvania 19104-6018, USA
Angelique Girard: Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Elizabeth P. Murchison: Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Sihem Cheloufi: Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Emily Hodges: Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Martin Anger: University of Pennsylvania, 433 South University Avenue, 205 Lynch Laboratories, Philadelphia, Pennsylvania 19104-6018, USA
Ravi Sachidanandam: Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Richard M. Schultz: University of Pennsylvania, 433 South University Avenue, 205 Lynch Laboratories, Philadelphia, Pennsylvania 19104-6018, USA
Gregory J. Hannon: Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA

Nature, 2008, vol. 453, issue 7194, 534-538

Abstract: Pseudogenes: Not without influence Over evolutionary time, many genes undergo duplication and one copy accumulates mutations that render it non-functional. These 'pseudogenes' are generally thought to be rather uninteresting, dead-end pieces of the genome. Yet there now appears to be more to it than that. Two groups report in this issue on pseudogenes that can in fact influence gene expression. The mechanism involves pairing of RNA antisense transcripts from pseudogenes with the mRNAs of protein-coding genes, forming a duplex RNA that is processed into endogenous siRNAs.

Date: 2008
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DOI: 10.1038/nature06904

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