Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

Toshiaki Watanabe (), Yasushi Totoki, Atsushi Toyoda, Masahiro Kaneda, Satomi Kuramochi-Miyagawa, Yayoi Obata, Hatsune Chiba, Yuji Kohara, Tomohiro Kono, Toru Nakano, M. Azim Surani, Yoshiyuki Sakaki and Hiroyuki Sasaki ()
Additional contact information
Toshiaki Watanabe: National Institute of Genetics, Research Organization of Information and Systems, Mishima 411-8540, Japan
Yasushi Totoki: Genome Annotation and Comparative Analysis Team, Computational and Experimental Systems Biology Group, and,
Atsushi Toyoda: Sequence Technology Team, RIKEN Genomic Sciences Center, Yokohama 230-0045, Japan
Masahiro Kaneda: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge
Satomi Kuramochi-Miyagawa: Graduate School of Medicine and Frontier Biosciences, Osaka University
Yayoi Obata: Tokyo University of Agriculture
Hatsune Chiba: National Institute of Genetics, Research Organization of Information and Systems, Mishima 411-8540, Japan
Yuji Kohara: School of Life Science, The Graduate University for Advanced Studies (SOKENDAI)
Tomohiro Kono: Tokyo University of Agriculture
Toru Nakano: Graduate School of Medicine and Frontier Biosciences, Osaka University
M. Azim Surani: Tokyo University of Agriculture
Yoshiyuki Sakaki: Genome Annotation and Comparative Analysis Team, Computational and Experimental Systems Biology Group, and,
Hiroyuki Sasaki: National Institute of Genetics, Research Organization of Information and Systems, Mishima 411-8540, Japan

Nature, 2008, vol. 453, issue 7194, 539-543

Abstract: Pseudogenes: Not without influence Over evolutionary time, many genes undergo duplication and one copy accumulates mutations that render it non-functional. These 'pseudogenes' are generally thought to be rather uninteresting, dead-end pieces of the genome. Yet there now appears to be more to it than that. Two groups report in this issue on pseudogenes that can in fact influence gene expression. The mechanism involves pairing of RNA antisense transcripts from pseudogenes with the mRNAs of protein-coding genes, forming a duplex RNA that is processed into endogenous siRNAs.

Date: 2008
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature06908 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:453:y:2008:i:7194:d:10.1038_nature06908

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature06908

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().