The ground state of embryonic stem cell self-renewal

Qi-Long Ying (), Jason Wray, Jennifer Nichols, Laura Batlle-Morera, Bradley Doble, James Woodgett, Philip Cohen and Austin Smith ()
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Qi-Long Ying: Center for Stem Cell and Regenerative Medicine, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 529, Los Angeles, California 90033, USA
Jason Wray: Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Jennifer Nichols: Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Laura Batlle-Morera: Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Bradley Doble: McMaster Stem Cell and Cancer Research Institute, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
James Woodgett: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Philip Cohen: University of Dundee
Austin Smith: Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

Nature, 2008, vol. 453, issue 7194, 519-523

Abstract: Embryonic stem cells: The ground state for self-renewal Embryonic stem (ES) cell self-renewal has generally been viewed as being dependent on the stimulation of various transcriptional pathways by exogenous factors in the culture media. A new study of mouse ES cells in a variety of cell culture condtions shows that, in fact, ES cell self-renewal does not rely on extrinsic instruction, and can be enabled by the elimination of factors that induce differentiation, and by inhibiting glycogen synthase kinase 3. This suggests that the ground state of the ES cell in the absence of extrinsic instruction is self-renewal — a display of self sufficiency that is more like that of a unicellular organism than the interdependence we expect of regular metazoan cells.

Date: 2008
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DOI: 10.1038/nature06968

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