HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

Nabieh Ayoub, Anand D. Jeyasekharan, Juan A. Bernal and Ashok R. Venkitaraman ()
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Nabieh Ayoub: The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
Anand D. Jeyasekharan: The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
Juan A. Bernal: The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
Ashok R. Venkitaraman: The Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK

Nature, 2008, vol. 453, issue 7195, 682-686

Abstract: DNA repair: Mobilizing chromatin factors The earliest known response to chromosomal DNA breakage is the phosphorylation of the histone H2AX. Ayoub et al. have now identified a dynamic change in chromatin that promotes this phosphorylation step. DNA breaks swiftly mobilize the chromatin factor HP1-β, and via a previously unrecognized signalling cascade involving a phosphorylation step carried out by casein kinase 2, H2AX becomes phosphorylated and the DNA damage response is under way.

Date: 2008
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DOI: 10.1038/nature06875

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