Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

Derek J. Richard, Emma Bolderson, Liza Cubeddu, Ross I. M. Wadsworth, Kienan Savage, Girdhar G. Sharma, Matthew L. Nicolette, Sergie Tsvetanov, Michael J. McIlwraith, Raj K. Pandita, Shunichi Takeda, Ronald T. Hay, Jean Gautier, Stephen C. West, Tanya T. Paull, Tej K. Pandita, Malcolm F. White () and Kum Kum Khanna ()
Additional contact information
Derek J. Richard: Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Emma Bolderson: Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Liza Cubeddu: Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK
Ross I. M. Wadsworth: Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK
Kienan Savage: Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Girdhar G. Sharma: Washington University School of Medicine, St Louis, Missouri 63108, USA
Matthew L. Nicolette: University of Texas at Austin, Austin, Texas 78712, USA
Sergie Tsvetanov: Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Michael J. McIlwraith: London Research Institute, Clare Hall Laboratories, Cancer Research UK, South Mimms, Hertfordshire EN6 3LD, U.K
Raj K. Pandita: Washington University School of Medicine, St Louis, Missouri 63108, USA
Shunichi Takeda: Kyoto University Graduate School of Medicine
Ronald T. Hay: Wellcome Biocentre, University of Dundee
Jean Gautier: Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
Stephen C. West: London Research Institute, Clare Hall Laboratories, Cancer Research UK, South Mimms, Hertfordshire EN6 3LD, U.K
Tanya T. Paull: University of Texas at Austin, Austin, Texas 78712, USA
Tej K. Pandita: Washington University School of Medicine, St Louis, Missouri 63108, USA
Malcolm F. White: Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK
Kum Kum Khanna: Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia

Nature, 2008, vol. 453, issue 7195, 677-681

Abstract: DNA damage: More protection for ssDNA Single-stranded DNA (ssDNA) in a cell is highly prone to degradation, so cells shield ssDNA from nucleases by coating it with ssDNA-binding proteins (SSBs). In eukaryotes, the canonical SSB is a heterotrimer known as RPA. In this work, Khanna and colleagues characterize a second SSB from human cells, which they call hSSB1. Unlike RPA, hSSB1 is a single protein. Its primary function seems to be in the cellular response to DNA damage.

Date: 2008
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DOI: 10.1038/nature06883

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