Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

Mariona Graupera, Julie Guillermet-Guibert, Lazaros C. Foukas, Li-Kun Phng, Robert J. Cain, Ashreena Salpekar, Wayne Pearce, Stephen Meek, Jaime Millan, Pedro R. Cutillas, Andrew J. H. Smith, Anne J. Ridley, Christiana Ruhrberg, Holger Gerhardt () and Bart Vanhaesebroeck ()
Additional contact information
Mariona Graupera: Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
Julie Guillermet-Guibert: Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
Lazaros C. Foukas: Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
Li-Kun Phng: Vascular Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
Robert J. Cain: King’s College London, New Hunt’s House, Guy’s Campus
Ashreena Salpekar: Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
Wayne Pearce: Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
Stephen Meek: Gene Targeting Laboratory, The Institute for Stem Cell Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JQ, UK
Jaime Millan: King’s College London, New Hunt’s House, Guy’s Campus
Pedro R. Cutillas: Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
Andrew J. H. Smith: Gene Targeting Laboratory, The Institute for Stem Cell Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JQ, UK
Anne J. Ridley: King’s College London, New Hunt’s House, Guy’s Campus
Christiana Ruhrberg: Institute of Ophthalmology, University College London
Holger Gerhardt: Vascular Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK
Bart Vanhaesebroeck: Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK

Nature, 2008, vol. 453, issue 7195, 662-666

Abstract: Phosphoinositide 3-kinase: Role of the p110a isoform The p110α isoform of phosphoinositide 3-kinase is shown to play a critical role in normal and pathological angiogenesis. In particular, it is needed to mediate the migration of endothelial cells downstream of VEGF receptor activation, acting upstream of RhoA. This finding suggests that p110a-selective inhibitors, in addition to their direct effects in inhibiting cancer cell proliferation, will also impact on pathological angiogenesis in tumours.

Date: 2008
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DOI: 10.1038/nature06892

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