Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

Yi Guo, Tobias C. Walther (), Meghana Rao, Nico Stuurman, Gohta Goshima, Koji Terayama, Jinny S. Wong, Ronald D. Vale, Peter Walter and Robert V. Farese ()
Additional contact information
Yi Guo: Department of Biochemistry and Biophysics,
Tobias C. Walther: Department of Biochemistry and Biophysics,
Meghana Rao: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Nico Stuurman: and
Gohta Goshima: and
Koji Terayama: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Jinny S. Wong: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Ronald D. Vale: and
Peter Walter: Department of Biochemistry and Biophysics,
Robert V. Farese: Department of Biochemistry and Biophysics,

Nature, 2008, vol. 453, issue 7195, 657-661

Abstract: Celluar lipids: Trouble in store Lipid droplets are found in nearly all eukaryotic cells and contain neutral lipids such as triacylglycerols and sterol esters. There is rapidly growing interest in the cell biology of lipid storage, largely due to the central role that these processes play in obesity and related metabolic diseases. Guo et al. have performed a genome-wide RNA interference screen in Drosophila cells and identify genes involved in lipid droplet formation and utilization. About 1.5% of all genes are involved in these processes.

Date: 2008
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DOI: 10.1038/nature06928

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